Speciality: Radiation Oncology

Sub Specialities:

Hon Clin Associate Professor, RCSI University of Medicine and Health Sciences

  • Prostate Cancer, including Prostate SABR.
  • Rectal Cancer.
  • Oesophageal Cancer.
  • Anal Cancer.
  • Palliative Radiotherapy.
  • Clinical Trials.
  • Biography

    Professor Brian O’Neill is a Consultant Radiation Oncologist with the St. Luke’s Radiation Oncology Network (SLRON) since 2008.

    Professor O’Neill is an Author of the National Cancer Control Programme (NCCP) clinical guidelines for upper and lower GI cancers and for Prostate Cancer. He is a former co-Chair of the Cancer Trials Ireland (CTI) GI disease-specific subgroup. Professor O’Neill is a board member of the St Lukes Institute for Cancer Research (SLICR) and the St. Luke’s Cancer Research Fund. He is a member of the NCCP National Colorectal Cancer Clinical Leads. Professor Brian O’Neill is the Irish Research Radiation Oncology Group Manager (IRROG) Site Lead at the St. Luke’s Centre in Beaumont Hospital.

    In addition to his clinical leadership, Professor O’Neill served on the SLRON Research Ethics and Research Management Committees, guiding ethical oversight and scientific integrity for clinical trials. He has served as Principal Investigator on several national and international trials including TRILARC (Rectal), Neo-AEGIS (Oesophageal), PACE-C (Prostate), and INSPIRE (Prostate SABR) and remains a national leader in multidisciplinary research.

    Professor O’Neill is the Author of numerous peer-reviewed publications and has lectured extensively. Professor O’Neill’s work is driven by a strong belief in patient-centred care, access equity, and the importance of Irish participation in global cancer research.

  • Research / Publications

    [>50 peer-reviewed publications]

    1. Intensity Modulated Moderately Hypofractionationated Radiotherapy Versus Stereotactic Body Radiotherapy for Prostate Cancer (PACE-C): Early Toxicity Results From a Randomised Open-label Phase III Non-inferiority Trial.
      A. Tree, V. Hinder, A. Chan, S. Tolan, P. Ostler, H. van der Voet, K. Kancherla, A. Loblaw, O. Naismith, S. Jain, A. Martin, D. Price, D. Brand, W. Chu, J. Armstrong, B. O’Neill, A. Duffton, J. Staffurth, G. Sasso, J. Pugh, G. Manning, S. Brown, S. Burnett, C. Griffin, E. Hall, N. van As.
      Lancet Oncology in press.
    2. Quality-of-Life Analysis of a Phase II Randomised Controlled Trial Comparing Three-Dimensional Conformal Radiotherapy and Intensity-Modulated Radiotherapy in Locally Advanced Rectal Cancer.
      Geary RL, Gillham C, McVey G, Armstrong J, Cunningham M, Rangaswamy G, Sharma D, Wallace N, Skourou C, Dunne M, Mahon M, Bradshaw S, O’Sullivan L, Marron J, Parker I, Shannon AM, McDermott R, Toomey S, Hennessy BT, O’Neill B.
      Clin Oncol (R Coll Radiol). 2025 Jan;37:103695.
    3. Patient choice of surgery or surveillance following a clinical complete response to neoadjuvant chemoradiotherapy for oesophageal carcinoma.
      Walsh TN, Kharytaniuk N, Furlong H, Sorensen J, O’Neill BD, Breathnach OS, Grogan L. Br J Surg. 2024 Jan 3;111(1).
    4. Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial.
      Reynolds JV, Preston SR, O’Neill B, Lowery MA, Baeksgaard L, Crosby T, Cunningham M, Cuffe S, Griffiths GO, Parker I, Risumlund SL, Roy R, Falk S, Hanna GB, Bartlett FR, Alvarez-Iglesias A, Achiam MP, Nilsson M, Piessen G, Ravi N, O’Toole D, Johnston C, McDermott RS, Turkington RC, Wahed S, Sothi S, Ford H, Wadley MS, Power D; Neo-AEGIS Investigators and Trial Group.
      Lancet Gastroenterol Hepatol. 2023 Sep 18:S2468-1253(23)00243-1.
    5. Quantification of Organ Motion During Chemoradiotherapy of Rectal Cancer Using Cone-Beam Computed Tomography.
      Chong I, Hawkins M, Hansen V, Thomas K, McNair H, O’Neill B, Aitken A, Tait D.
      Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):e431-8.
    6. Non-Operative Treatment Following Chemo-Radiotherapy for Rectal Cancer. O’Neill BDP, Gina Brown, Bill Heald, David Cunningham and Diana M. Tait.
      Lancet Oncology 2007 July;8(7): 625-633.
  • Professional Bodies
    • Cancer Trials Ireland
    • European Society for Therapeutic Radiology and Oncology (ESTRO)
    • American Society for Therapeutic Radiology and Oncology (ASTRO)